Hi, yes I have, unfortunately(
I started in April 2022 on .50 for the first 3 weeks and then all of a sudden my appetite was back bad so I called the dr and he upped my dosage to 1. I had constipation for about 3 weeks and that for me was the worst! I guess it's fair to say the higher dosage caused this side effect since I had none on 0.5, only the nausea, exhaustion and (pardon me) diarrhea. I did, however, managed to get rid of it over time. Beetroots, prunes, different juices...still not sure what exactly helped))